4-Nitro Benzal acetone

4-Nitro Benzal acetone - Names and Identifiers

Name	4-(4-NITROPHENYL)-3-BUTEN-2-ONE
Synonyms	NSC 68341 p-Nitrobenzalacetone 4-Nitro Benzal acetone p-Nitrobenzylideneacetone Methyl 4-nitrostyryl ketone Methyl p-nitrostyryl ketone 4-(4-NITROPHENYL)-3-BUTEN-2-ONE 3-Buten-2-one, 4-(4-nitrophenyl)-
CAS	3490-37-7
EINECS	200-258-5

4-Nitro Benzal acetone - Physico-chemical Properties

Molecular Formula	C10H9NO3
Molar Mass	191.18
Melting Point	254-256℃
Solubility	Chloroform, Ethyl Acetate (Slightly)
Appearance	Solid
Color	Off-White to Pale Yellow
Storage Condition	2-8°C
Physical and Chemical Properties	Colorless crystals. Melting point 110 ℃.

4-Nitro Benzal acetone - Reference Information

purpose

This product is a new anticoagulant intermediate.

production method

4-p-nitrophenyl-4-hydroxybutanone-2 is obtained by the addition of p-nitrobenzaldehyde and acetone, it is obtained by eliminating dehydration with sulfuric acid. P-nitrobenzaldehyde was dissolved in acetone, cooled to about 5 °c, and sodium hydroxide solution was added dropwise with stirring. After the addition, the mixture was stirred at room temperature for 20min and neutralized to pH = 4-5 by addition of 15% sulfuric acid. The precipitate was filtered off, and the filtrate was recovered from acetone. The residue was added to 7 times the amount of 15% sulfuric acid, and heated and hydrolyzed for 30min. The product was obtained by cooling, filtering, washing the filter cake with water and recrystallization in ethanol. The yield was 80%.

Last Update：2024-04-09 15:16:57